Table 1.
Subject characteristics.
| PCA | AD | HC | |
|---|---|---|---|
|
|
|||
| N | 11 | 11 | 15 |
| Age (years) | 64.3 ± 7.0 | 65.6 ± 7.3 | 63.7 ± 4.7 |
| Sex | 6F, 5M | 5F, 6M | 3F, 12M |
| Education (years) | 15.5 ± 2.7 | 16.5 ± 2.1 | 16.1 ± 2.4 |
| Duration of symptoms (years) | 5.5 ± 3.1 | 3.4 ± 1.4 | N/A |
| TSPO genotype (HAB:MAB)a | 7:4 | 3:8 | 4:11 |
| Non-steroidal anti-inflammatory drug use | 27.3% | 27.3% | 40.0% |
| Cholinesterase inhibitor use | 54.5% | 81.8% | 0% |
| Mini Mental State Exam score | 18.4 ± 6.2 | 21.5 ± 4.7 | 29.9 ± 0.4 b |
| WAIS-III Block Designc | 29.8 ± 5.9d | 43.8 ± 9.5 | |
| % unable to perform Block Design | 36% | 0% | |
| HVLT-R Delayed Recallc | 24.1 ± 12.1 | 22 ± 6.0 | |
| BVMT-R Delayed Recallc | 21.4 ± 6.4 | 20 ± 3.3 | |
| Phonemic (FAS) Fluencyc | 34.1 ± 14.6 | 46.2 ± 17.1 | |
| Category Fluencyc | 22.3 ± 10.2 | 28.6 ± 14.5 | |
a
One PCA patient did not have TSPO binding status determined and was assumed to be HAB based on cerebellar binding compared to MABs.
b
P < 0.0001 vs. PCA and AD (Oneway ANOVA with Tukey post-hoc test)
c
Test not performed or unable to be completed in some PCA patients
d
P = 0.009 vs. AD (two-tailed t test)
PCA = Posterior cortical atrophy, AD = amnestic Alzheimer’s disease, HC = healthy controls, HAB = High affinity binder, MAB = mixed affinity binder, MMSE – Mini Mental State Exam, HVLT-R – Hopkins Verbal Learning Test - Revised, BVMT-R – Brief Visuospatial Memory Test - Revised. WAIS-III – Wechsler Adult Intelligence Scale, Third Edition. Data given as mean ± SD.