Table 2.
Regional 11C-PBR28 binding in patients with posterior cortical atrophy, amnestic Alzheimer’s disease, and in healthy controls.
|
VT/fP (mL · cm−3)
|
SUVR
|
|||||
|---|---|---|---|---|---|---|
| PCA (n = 11) | AD (n = 11) | HC (n = 15) | PCA (n = 11) | AD (n = 11) | HC (n = 15) | |
|
| ||||||
| Prefrontal | 181.5 ± 56.5 | 192.8 ± 52.6 | 158.0 ± 52.0 | 1.57 ± 0.17 | 1.61 ± 0.18g | 1.40 ± 0.18 |
| Superior parietal | 263.3 ± 86.1d | 185.5 ± 80.6 | 159.0 ± 79.7 | 2.09 ± 0.24c,f | 1.58 ± 0.26 | 1.42 ± 0.26 |
| Inferior parietal | 234.7 ± 61.3b | 194.2 ± 57.3 | 147.0 ± 56.6 | 1.89 ± 0.20c,e | 1.60 ± 0.22h | 1.31 ± 0.22 |
| Precuneus | 214.3 ± 65.9a | 185.9 ± 61.4 | 139.6 ± 60.7 | 1.77 ± 0.22c | 1.57 ± 0.24h | 1.26 ± 0.24 |
| Occipital | 239.6 ± 66.9a | 180.1 ± 61.7 | 166.3 ± 61.0 | 2.12 ± 0.20c,f | 1.55 ± 0.22 | 1.48 ± 0.22 |
| Superior temporal | 181.5 ± 57.1 | 184.3 ± 53.3 | 150.4 ± 52.7 | 1.55 ± 0.14b | 1.56 ± 0.15h | 1.34 ± 0.15 |
| Mid & inf temporal | 188.1 ± 58.3 | 204.8 ± 54.4g | 146.0 ± 53.8 | 1.60 ± 0.15c | 1.63 ± 0.16i | 1.29 ± 0.16 |
| Hippocampus | 109.5 ± 44.1 | 130.5 ± 41.2 | 89.1 ± 40.8 | 0.94 ± 0.12a | 1.07 ± 0.12i | 0.81 ± 0.12 |
| Entorhinal | 196.9 ± 87.3 | 256.1 ± 77.6h | 149.3 ± 80.5 | 1.41 ± 0.19 | 1.69 ± 0.21i,j | 1.22 ± 0.21 |
| Cerebellum | 111.7 ± 37.2 | 113.5 ± 34.8 | 111.2 ± 34.4 | N/A | N/A | N/A |
Group differences assessed using used univariate ANOVA with diagnosis and TSPO genotype as fixed factors, and age and education as covariates.
PCA > HC, P < 0.05;
PCA > HC, P < 0.01;
PCA > HC, P < 0.001
PCA > AD, P < 0.05;
PCA > AD, P < 0.01;
PCA > AD, P < 0.001
AD > HC, P < 0.05;
AD > HC, P < 0.01;
AD > HC, P < 0.001
AD > PCA, P < 0.01
PCA = posterior cortical atrophy, AD = amnestic Alzheimer’s disease, HC = healthy controls, VT/fP = total distribution volume/free fraction of radioligand, SUVR = standardized uptake value ratio. 11C-PBR28 binding values corrected for age, education, and TSPO genotype. Data are presented as mean ± SD.