Table 5. Correlation between the genotypes of the MLXIPL, BUD13 and ZNF259 SNPs and serum lipid levels in the Mulao and Han populations.
Lipid | SNP | Affected allele/Other allele | Affected genotype/Other genotype | Beta | Std. error | t | P-value |
---|---|---|---|---|---|---|---|
Mulao plus Han | |||||||
TC | BUD13 rs10790162 | AA, GA/GG | 0.167 | 0.049 | 3.407 | 0.001 | |
TG | BUD13 rs10790162 | A/G | 0.248 | 0.048 | 5.163 | <1 × 10−7 | |
LDL-C | BUD13 rs17119975 | G/A | 0.513 | 0.183 | 2.800 | 0.005 | |
BUD13 rs10790162 | A/G | 0.099 | 0.039 | 2.546 | 0.011 | ||
BUD13 rs13235543 | T/C | 0.149 | 0.069 | 2.164 | 0.031 | ||
ApoA1 | BUD13 rs13235543 | TT, CT/CC | 0.097 | 0.031 | 3.093 | 0.002 | |
BUD13 rs11556024 | T/C | 0.060 | 0.027 | 2.234 | 0.025 | ||
ApoB | BUD13 rs13235543 | TT, CT/CC | 0.097 | 0.031 | 3.093 | 0.002 | |
BUD13 rs10790162 | A/G | 0.058 | 0.024 | 2.405 | 0.016 | ||
ApoA1/ApoB | BUD13 rs10790162 | AA, GA/GG | −0.083 | 0.030 | −2.754 | 0.006 | |
BUD13 rs11556024 | T/C | 0.133 | 0.051 | 2.611 | 0.009 | ||
BUD13 rs13235543 | T/C | −0.113 | 0.053 | −2.138 | 0.033 | ||
Mulao | |||||||
TC | BUD13 rs10790162 | AA, GA/GG | 0.200 | 0.071 | 2.836 | 0.005 | |
TG | BUD13 rs10790162 | AA, AG/GG | 0.292 | 0.062 | 4.744 | 2 × 10−5 | |
BUD13 rs13235543 | TT, CT/CC | 0.248 | 0.101 | 2.450 | 0.015 | ||
ZNF259 rs964184 | GG, CG/CC | −0.401 | 0.192 | −2.083 | 0.037 | ||
LDL-C | BUD13 rs10790162 | A/G | 0.167 | 0.067 | 2.485 | 0.013 | |
ApoA1 | MLXIPL rs35332062 | TT, CT/CC | 0.510 | 0.155 | 3.284 | 0.001 | |
MLXIPL rs35332062 | T/C | −0.427 | 0.179 | −2.392 | 0.017 | ||
ApoB | BUD13 rs13235543 | TT, CT/CC | 0.214 | 0.059 | 3.608 | 4 × 10−4 | |
ApoA1/ApoB | BUD13 rs13235543 | T/C | −0.180 | 0.090 | −1.999 | 0.046 | |
BUD13 rs10790162 | A/G | −0.124 | 0.063 | −1.978 | 0.048 | ||
Han | |||||||
TC | MLXIPL rs799161 | T/C | 0.127 | 0.062 | 2.042 | 0.042 | |
TG | BUD13 rs17119975 | G/A | 0.308 | 0.081 | 3.826 | 1 × 10−4 | |
BUD13 rs10790162 | A/G | 0.268 | 0.083 | 3.211 | 0.001 | ||
BUD13 rs17119975 | GG, AG/AA | −0.561 | 0.240 | −2.340 | 0.020 | ||
HDL-C | MLXIPL rs35332062 | T/C | 0.788 | 0.127 | 6.218 | <1 × 10−7 | |
BUD13 rs13235543 | T/C | −0.407 | 0.116 | −3.501 | 5 × 10−4 | ||
BUD13 rs11556024 | TT, CT/CC | 0.175 | 0.061 | 2.852 | 0.004 | ||
MLXIPL rs3812316 | GG, CG/CC | −0.329 | 0.126 | −2.614 | 0.009 | ||
LDL-C | MLXIPL rs799161 | T/C | 0.196 | 0.066 | 2.990 | 0.003 | |
ApoA1 | BUD13 rs11556024 | T/C | 0.095 | 0.028 | 3.465 | 0.001 | |
ApoB | BUD13 rs10790162 | A/G | 0.055 | 0.017 | 3.198 | 0.001 | |
ZNF259 rs2075290 | GG, AG/AA | −0.048 | 0.020 | −2.396 | 0.017 | ||
BUD13 rs11556024 | TT, CT/CC | −0.039 | 0.019 | −2.018 | 0.044 | ||
ApoA1/ApoB | BUD13 rs11556024 | TT, CT/CC | 0.182 | 0.050 | 3.642 | 2 × 10−4 | |
BUD13 rs10790162 | AA, GA/GG | −0.091 | 0.031 | −2.974 | 0.003 | ||
MLXIPL rs799161 | T/C | −0.107 | 0.036 | −2.999 | 0.003 |
Multivariable linear regression analyses with stepwise modeling were performed to assess the correlation between serum lipid levels and genotypes in Mulao, Han, and combined the Mulao and Han populations.