Table 1.

Top Genes with Evidence of a Coevolutionary Relationship with (a) EQ and (b) Brain Mass in the Expanded 13-Species Data Set

Gene	Gene Name	t11	R2	Nominal-P	Permutation-P
(a) EQ
HTR5A	5-Hydroxytryptamine (Serotonin) Receptor 5A	6.267	0.751	<0.001	0.007
ZBTB16	Zinc Finger And BTB Domain Containing 16	4.784	0.638	<0.001	0.006
PPIL2	Peptidylprolyl Isomerase (Cyclophilin)-Like 2	3.570	0.495	0.002	0.067
DHDH	Dihydrodiol Dehydrogenase	3.453	0.478	0.003	0.045
TMEM86A	Transmembrane Protein 86A	3.441	0.477	0.003	0.033
ACOT8	Acyl-CoA Thioesterase 8	3.367	0.466	0.003	0.037
DRP2	Dystrophin Related Protein 2	3.147	0.432	0.005	0.047
NUFIP2	Nuclear Fragile X Mental Retardation Protein Interacting Protein 2	3.119	0.428	0.005	0.054
RNASEH2A	Ribonuclease H2, Subunit A	2.983	0.406	0.006	0.018
DARS2	Aspartyl-TRNA Synthetase 2, Mitochondrial	2.805	0.377	0.009	0.111
ST3GAL1	ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 1	2.746	0.367	0.010	0.100
(b) Brain mass
HTR5A	5-Hydroxytryptamine (Serotonin) Receptor 5A	3.533	0.490	0.002	0.006
SPRY4	Sprouty Homolog 4	3.353	0.464	0.003	0.003
ZBTB11	Zinc Finger And BTB Domain Containing 11	2.808	0.377	0.009	0.013
LMBR1L	Limb Development Membrane Protein 1-Like	2.343	0.297	0.019	0.036
FBN1	Fibrillin 1	2.254	0.281	0.023	0.010
LUM	Lumican	2.195	0.270	0.025	0.018
ECI2	Enoyl-CoA Delta Isomerase 2	2.178	0.267	0.026	0.013
GRIN3A	Glutamate Receptor, Ionotropic, N-Methyl-d-Aspartate 3A	2.149	0.262	0.027	0.034
FKBP10	FK506 Binding Protein 10	2.063	0.247	0.032	0.028
TRAFD1	TRAF-Type Zinc Finger Domain Containing 1	2.037	0.242	0.033	0.122
ZCCHC6	Zinc Finger, CCHC Domain Containing 6	2.033	0.241	0.033	0.027
BDH1	3-Hydroxybutyrate Dehydrogenase, Type 1	1.863	0.211	0.045	0.031
SERPIND1	Serpin Peptidase Inhibitor, Clade D (Heparin Cofactor), Member 1	1.834	0.205	0.047	0.017