Table 2. Summary risk estimates of the association between vegetables and fruit and NPC risk.
| Sub-groups | Vegetables | Fruit | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Studies, n | RR(95%CI)a | Pb | Q value | I2 (%) | Pc | Pd | Studies, n | RR(95%CI)a | Pb | Q value | I2 (%) | Pc | Pd | |
| All | 11 | 0.60(0.47–0.76) | 0.00 | 20.0 | 50.0 | 0.03 | 0.81 | 10 | 0.67(0.58–0.70) | 0.00 | 9.0 | 0.0 | 0.78 | 0.60 |
| Case-control | 11 | 0.60(0.47–0.76) | 0.00 | 20.0 | 50.0 | 0.03 | 0.81 | 9 | 0.61(0.54–0.69) | 0.00 | 8.0 | 0.0 | 0.84 | 0.68 |
| Sources of control | ||||||||||||||
| Population-based | 7 | 0.80(0.65–0.99) | 0.04 | 6.0 | 0.0 | 0.84 | 0.43 | 4 | 0.58(0.47–0.71) | 0.00 | 3.1 | 3.3 | 0.38 | 0.75 |
| Hospital-based | 4 | 0.47(0.380.58) | 0.00 | 4.9 | 38.9 | 0.18 | 0.51 | 5 | 0.63(0.54–0.74) | 0.00 | 4.0 | 0.0 | 0.96 | 0.47 |
| Ethnicity | ||||||||||||||
| Asia | 7 | 0.58(0.39–0.85) | 0.00 | 17.6 | 65.9 | 0.01 | 0.67 | 7 | 0.62(0.55–0.70) | 0.00 | 6.1 | 0.0 | 0.59 | 0.69 |
| Caucasian | 3 | 0.65(0.45–0.94) | 0.03 | 2.9 | 13.0 | 0.32 | 0.24 | 3 | 0.66(0.49–0.91) | 0.01 | 2.0 | 0.0 | 0.68 | 0.42 |
| Publication language | ||||||||||||||
| Chinese | 1 | 0.44(0.27–0.72) | -- | -- | -- | -- | -- | 2 | 0.63(0.56–0.70) | 0.00 | 1.1 | 0.0 | 1.00 | 0.52 |
| English | 10 | 0.64(0.55–0.75) | 0.00 | 17.9 | 49.9 | 0.04 | 0.73 | 8 | 0.66(0.57–0.77) | 0.00 | 7.0 | 0.0 | 0.80 | 0.79 |
| Number of cases | ||||||||||||||
| <200 | 5 | 0.58(0.44–0.77) | 0.00 | 4.3 | 8.0 | 0.36 | 0.46 | 4 | 0.63(0.49–0.82) | 0.00 | 3.0 | 0.0 | 0.78 | 0.51 |
| ≥200 | 6 | 0.59(0.41–0.86) | 0.01 | 15.4 | 67.6 | 0.01 | 0.52 | 6 | 0.63(0.55–0.71) | 0.00 | 4.9 | 0.0 | 0.48 | 0.69 |
| Adjustments | ||||||||||||||
| Smoking, yes | 6 | 0.57(0.39–0.84) | 0.00 | 18.8 | 73.4 | 0.00 | 0.63 | 4 | 0.69(0.56–0.86) | 0.00 | 3.0 | 0.0 | 0.78 | 0.40 |
| no | 5 | 0.63(0.47–0.83) | 0.00 | 4.0 | 0.0 | 0.88 | 0.49 | 6 | 0.60(0.53–0.69) | 0.00 | 5.0 | 0.0 | 0.63 | 0.58 |
| Alcohol, yes | 3 | 0.65(0.45–0.94) | 0.03 | 2.9 | 13.0 | 0.32 | 0.16 | 2 | 0.74(0.55–1.02) | 0.06 | 1.1 | 0.0 | 0.68 | 0.73 |
| no | 8 | 0.58(0.43–0.79) | 0.00 | 17.6 | 60.3 | 0.01 | 0.65 | 8 | 0.61(0.54–0.69) | 0.00 | 7.1 | 0.0 | 0.78 | 0.49 |
aThe random effect model was adopted the pooling method if I2>50%; otherwise, the fixed effect model (I2<50%) was used as the pooling method.
bthe P value for RR; cthe p value for heterogeneity; dthe p value for publication bias.