Fig. 3.—

Functional analysis of L. erinacea, L. japonicum and B. lanceolatum LXRs LBD. Dose–response curves for LXRs activation by T0901317 (A), 24(S)-hydroxycholesterol (B), 25-hydroxycholesterol (C) and 24(S),25-epoxycholesterol (D) for H. sapiens LXRβ (○), L. erinacea LXRβ (Δ) and LXRα (∇), L. japonicum (◊) and B. lanceolatum (□); EC₅₀ and maximum normalized-fold activation (Max_{fold A}) values for HsaLXRβ, LerLXRβ and LerLXRα (E). The activation of LXR was normalized to the control condition (DMSO without ligand) represented by 10 ^− 2 M. Hsa stands for H. sapiens, Ler stands for L. erinacea, Lja stands for L. japonicum and Bla stands for B. lanceolatum. The values represented are the means with ±SE from three separate experiments. *P < 0.05, **P < 0.01, ***P < 0.001.