Skip to main content
. Author manuscript; available in PMC: 2017 Apr 5.
Published in final edited form as: Sci Transl Med. 2016 Mar 2;8(328):328ra28. doi: 10.1126/scitranslmed.aac8228

Fig. 2. ATRX loss decreases median survival in mice bearing SB-generated GBMs.

Fig. 2

(A) Kaplan-Meier survival curves of C57BL/6 mice bearing SB-induced tumors (p=0.0032, Mantel log-rank test). (B) Representative brain tumors with histologic hallmarks of glioblastoma (GBM): pseudopalisading necrosis and nuclear atypia (black arrows and blue arrow, respectively). (C) Tumors with addition of shATRX plasmid are larger at earlier time points than tumors with shp53/NRAS alone and show ATRX loss throughout the tumor.