Fig. 5.—

Diversification of the amino acid sequences of TXY motifs in the activation loops among members from each of the four MAPK subfamilies. Middle table: The number of members from an MAPK subfamily had a specific TXY motif named at the top of the table. Right panel: Logos showing the sequence conservation of the TXY motifs in the four MAPK subfamilies. The inserted logo shows the sequence conservation of the TXY motifs in Slt2/Smk1-MAPK subfamily members from the Saccharomycetes fungi. Left panel: Phylogenetic tree of the four MAPK subfamilies (simplified from fig. 2A). The digits in parentheses are the number of members in an MAPK subfamily.