Table 2. Pooled odds ratios for recessive model for the CD24 Ala57Val polymorphism.
| Disease | Variables | No. of studies | Test of association | Test of heterogeneity | ||
|---|---|---|---|---|---|---|
| OR (95% CI) | Pz | Phet | I2 | |||
| MS | Total | 6 | 2.28 (1.68–3.10) | <0.001 | 0.364 | 8.1% |
| Subgroup analysis by HWE status | ||||||
| Deviation from HWE | 2 | 2.66 (1.59–4.46) | <0.001 | 0.533 | 0.0% | |
| No deviation from HWE | 4 | 2.09 (1.42–3.06) | <0.001 | 0.219 | 32.2% | |
| Subgroup analysis by ethnicity | ||||||
| Caucasians | 5 | 2.30 (1.66–3.20) | <0.001 | 0.247 | 26.2% | |
| Poser criteriaa | 1 | 1.01 (0.44–2.32) | 0.990 | NA | NA | |
| McDonald criteriab | 4 | 2.68 (1.86–3.87) | <0.001 | 0.801 | 0.0% | |
| SLE | Total | 5 | 1.71 (1.32–2.22) | <0.001 | 0.188 | 35.0% |
| Subgroup analysis by ethnicity | ||||||
| Caucasians | 4 | 1.71 (1.31–2.24) | <0.001 | 0.105 | 51.2% | |
| Subjects ≥ 1000c | 1 | 2.55 (1.57–4.14) | <0.001 | NA | NA | |
| Subjects < 1000d | 3 | 1.38 (1.00–1.92) | 0.057 | 0.375 | 0.0% | |
CI, confidence interval; HWE, Hardy-Weinberg equilibrium; MS, multiple sclerosis; NA, not available; OR, odds ratio; Phet, P-value for heterogeneity; Pz, P-value for overall effect; SLE, systemic lupus erythematosus.
aCaucasian studies which used Poser criteria.
bCaucasian studies which used McDonald criteria.
cCaucasian studies which included no less than 1000 subjects.
dCaucasian studies which included less than 1000 subjects.