Skip to main content
. 2014 Jul 4;4:5573. doi: 10.1038/srep05573

Figure 1. E3 ubiquitin ligases in the ubiquitin-proteasome system (UPS) play paradoxical roles in proteolysis and transcription.

Figure 1

(a) Protein degradation mediated by the UPS. E3 ubiquitin ligases determine the substrate specificity of UPS-dependent proteolysis. The specific biochemical reactions depend on the type of proteins in the UPS. (b) An E3 ubiquitin ligase can participate in the transcriptional activation of transcription factors, which also undergo proteolysis facilitated by the same E3 ligase.