Table 1.
MIC values of teixobactin homologues in μg/mL.a
|
Staphylococcus epidermidis ATCC 14990 |
Streptococcus salivarius ATCC 13419 |
Enterococcus durans ATCC 6056 |
Bacillus subtilis ATCC 6051 |
Escherichia coli ATCC 10798 |
|
|---|---|---|---|---|---|
| Arg10-teixobactin | 1 | 1 | 4 | 2 | >32 |
| lipobactin 1 | 4 | 4 | 8 | 4 | >32 |
| Ac-Δ1–5-Arg10-teixobactin | >32 | >32 | >32 | >32 | >32 |
| Lys6,Arg10-teixobactin | >32 | >32 | >32 | >32 | >32 |
| Arg10,Lys11-teixobactin | >32 | >32 | >32 | >32 | >32 |
| Lys9,Arg10-teixobactin | 1 | 1 | 4 | 1 | >32 |
| Chg6,Arg10,Chg11-teixobactin | 1 | 0.5 | 2 | 1 | >32 |
| Ala7,Arg10-teixobactin | 32 | 16 | >32 | 32 | >32 |
| D-Dap8,Arg10-teixobactin | 2 | 1 | 4 | 1 | >32 |
| vancomycin | 0.5 | 0.5 | 0.5 | 1 | >32 |
| teixobactin | 0.06 | 0.03 | 0.5 | 0.06 | >32 |
a
All teixobactin homologues were prepared and studied as the trifluoroacetate salts. The Staphylococcus, Streptococcus, Enterococcus, and Bacillus species are non-pathogenic (BSL-1) Gram-positive bacteria. The E. coli serves as a Gram-negative control. Vancomycin and teixobactin serve as positive controls.