Figure 2. Oncogenes driving pancreatic cancer hack the endogenous pancreas regenerative program.

The regeneration of damaged pancreas requires the coordinated and interdependent activities of multiple cell lineages to rebuild the characteristic structure and function of the damaged tissue. We posit that cell-specific super enhancer networks are integrated into a carefully choreographed whole through continuous exchange of signals (shown much simplified). Both the super enhancer networks and the signals that integrate them offer novel targets for therapeutic intervention.