Figure 4. Putative therapeutic interventions directly or indirectly target super enhancers and epigenetic networks in multiple cell lineages in pancreatic regenerative program.

A range of novel drugs (shown in red) directly or indirectly disrupt super enhancers by targeting epigenetic modifiers that integrate the regenerative super enhancer-driven sub-programs in each of the epithelial and stromal compartments that participate in the hacked repair program.