Table 4. The odds ratio for rapid CKD progression [rapid progression (eGFR-ADR >3 ml/min/1.73m2) vs. non-progression (eGFR-ADR <1 ml/min/1.73m2)] of different matrices of kidney function in multiple logistic regression.
| Kidney function | Model 1 | Model 2 | Model 3 |
|---|---|---|---|
| Baseline eGFR | Baseline CKD stage | Latest CKD stage | |
| per 1 ml/min/1.73m2 | 0.995 (0.991, 0.999)** | — | — |
| Stage 1 | — | Ref | Ref |
| Stage 2 | — | 1.02 (0.56, 1.88) | 1.04 (0.50, 2.14) |
| Stage 3 | — | 0.86 (0.50, 1.49) | 1.90 (0.96, 3.74) |
| Stage 4 | — | 1.33 (0.77, 2.30) | 5.17 (2.60, 10.25)*** |
| Stage 5 | — | 1.26 (0.73, 2.18) | 19.83 (10.05, 39.10)*** |
| Age > 60 years (ref: ≤ 60) | 0.68 (0.56, 0.81) *** | 0.68 (0.57, 0.82)*** | 0.55 (0.44, 0.68) *** |
| Sex (Ref: female) | 0.84 (0.72, 0.98)* | 0.87 (0.75, 1.02) | 1.09 (0.92, 1.30) |
| Diabetes (Ref: no) | 1.72 (1.48, 2.00) *** | 1.69 (1.46, 1.97)*** | 1.64 (1.38, 1.95) *** |
| MAP (mmHg) | 1.02 (1.01, 1.03)*** | 1.02 (1.01, 1.03)*** | 1.01 (0.999, 1.014)*** |
| Proteinuria (Ref: no) | 1.89 (1.63, 2.20) *** | 1.83 (1.57, 2.13)*** | 1.47 (1.23, 1.74) *** |
| Dyslipidemia (Ref: no) | 1.10 (0.85, 1.43) | 1.12 (0.86, 1.45) | 1.29(0.95, 1.75) |
| CVD (Ref: no) | 1.07 (0.86, 1.33) | 1.07 (0.85, 1.33) | 1.02 (0.79, 1.31) |
| Smoking (Ref: no) | 1.12 (0.88, 1.43) | 1.11 (0.87, 1.42) | 1.11 (0.85, 1.46) |
Significance:
* p-value<0.05;
** p-value <0.01;
*** p-value<0.001
Abbreviations: CKD, chronic kidney disease; eGFR-ADR: estimated glomerular filtration rate—annual decline rate. CVD, cardiovascular disease; ADR: annual decline rate; MAP: mean arterial pressure