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. 2017 Apr 5;12(4):e0174272. doi: 10.1371/journal.pone.0174272

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© 2017 Zhang, Kong

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 5 — (a) Morphine induced reinstatement of drug-seeking behavior (n = 41). (b) Locomotor activity increased in the reinstatement test when compared to the last extinction day. (c) The active pokes in the successful reinstatement group (n = 20) were higher than in the failed reinstatement group on the reinstatement test (n = 21). (d) There was no difference in the inactive pokes between the successful reinstatement group and the failed instatement group. (e) Locomotor activity increased in the reinstatement test for both the successful reinstatement group and the failed reinstatement group. (f) The increase in locomotor activity was not correlated with the increase in active pokes in the successful reinstatement group or the failed reinstatement group. *** p < 0.001, compared to the last extinction session. ### p < 0.001, compared to the failed reinstatement group. &&& p < 0.001, post hoc test compared to the failed reinstatement group on the same session.