Table 4.

fMRI BOLD response to milkshake taste vs crosshairs. Main effects and interaction effect of the 2 (Treatment Group) × 2 (Time) ANCOVA controlling for baseline body mass index (N=34)

	Hemi		Peak	Peak	Peak
	sphere	k	F	Z	p(unc)	Xa	y	z
Treatment main effectsb
Time main effects
Anterior Cingulate	L	9	21.99	4.17	1.56E-05	−18	38	15
Thalamus	L	39	19.34	3.93	4.29E-05	−3	−25	7.5
Precuneus	L	5	19.11	3.91	4.72E-05	−12	−37	2.5
Hippocampus	L	5	15.50	3.53	0.000209	−18	−31	−2.5
Medial Frontal Gyrus - Rectus	L	20	18.77	3.87	5.4E-05	−9	26	−12.5
Anterior intraparietal sulcus	R	17	16.82	3.67	0.00012	33	−37	22.5
Superior/Medial frontal		4	16.76	3.67	0.000123	27	14	17.5
Supp Motor Area	L	5	16.70	3.66	0.000126	0	17	67.5
Angular Supramarginal Gyrus	R	8	16.57	3.65	0.000133	42	−49	32.5
Precuneus	L	10	15.54	3.53	0.000205	−3	−64	50
Medial Frontal Gyrus Supp Motor Area	R	4	15.29	3.51	0.000229	6	−22	60
Medial Frontal Gyrus Frontal Sup Medial	R	4	13.12	3.25	0.000585	3	35	47.5
Interaction Effect
BWL / control × baseline / 12 week scan
Orbitofrontal Cortex	R	6	22.30	4.20	1.34E-05	24	35	5
Uvula	L	8	19.63	3.96	3.83E-05	−3	−64	−40
Medial Prefrontal Cortex	R	8	17.29	3.72	9.86E-05	21	17	17.5
Caudate	R	4	15.50	3.53	0.000208	21	8	20
Central sulcus	R	12	15.27	3.50	0.00023	30	−19	27.5
Middle Temporal Gyrus	R	4	13.07	3.24	0.000596	36	−61	12.5
Insula	L	4	12.71	3.20	0.0007	−33	8	12.5

Threshold: p < .001, k_E = 3

R = right, L = left;

k = cluster size in voxels

Note that 5 voxels of the L precuneus and 5 voxels of the L hippocampus were contained within the cluster of 39 voxels of the L thalamus. Four voxels of the R caudate were contained within the cluster of 8 voxels of the R Medial Prefrontal Cortex. We used WFUPickAtlas within Xjview (http://www.alivelearn.net/xjview) for neuroanatomical labelling.

Peak F= F value of the peak of the cluster

Peak Z = Z value of the peak of the cluster

Peak p (unc) = Peak p (uncorrected)

^ax, y, z coordinates are in Montreal Neurological Institute space.

^bNo effect met the threshold