Table 7.

Hierarchical linear regressions using FTO genotype and right caudate activation response to milkshake taste to predict % weight loss (Kg) after Behavioral weight loss (BWL) where N=17.

	Dependent variable: % Weight loss baseline to 12 weeks (n = 15)
		R2a	F(2,14)	bb	SE	t	p
		0.73	13.90
FTO1 rs9939609 (A/A or T/A =10/15)c				0.55	0.87	3.89	0.003
Frontostriatal circuit				−0.75	0.85	−5.37	<0.0001
Other regions				0.38	1.09	2.66	0.02
	Dependent variable: % Weight loss baseline to 36 weeks (n = 13)
		R2a	F(2,12)	bb	SE	t	p
		0.60	6.89
FTO1 rs9939609 (A/A or T/A = 8/13)c				0.49	2.03	2.62	0.03
Frontostriatal circuit				−0.63	2.01	−3.34	0.009
Other regions				−0.14	2.76	−0.76	0.47
	Dependent variable: % Weight loss from baseline to 60 weeks (n = 15)
		R2a	F(2,14)	bb	SE	t	p
		0.52	6.14
FTO1 rs9939609 (A/A or T/A =10/15)c				0.31	3.25	1.62	0.14
Frontostriatal circuit				−0.68	3.14	−3.67	0.004
Other regions				−0.22	4.04	−1.17	0.27
	Dependent variable: % Weight loss from 12 to 36 weeks (n = 13)
		R2a	F(2,12)	bb	SE	t	p
		0.26	2.39
FTO1 rs9939609 (A/A or T/A = 8/13)c				0.23	2.14	0.93	0.38
Frontostriatal circuit				−0.31	2.12	−1.20	0.26
Other regions				−0.45	2.91	−1.76	0.11
	Dependent variable: % Weight loss from 12 to 60 weeks (n = 15)
		R2a	F(2,14)	bb	SE	t	p
		0.34	3.37
FTO1 rs9939609 (A/A or T/A =10/15)c				0.12	3.49	0.52	0.62
Frontostriatal circuit				−0.48	3.37	−2.20	0.05
Other regions				−0.43	4.34	−1.92	0.08
Dependent variable: % Weight loss 36 to 60 weeks (n = 13)
		R2a	F(2,12)	bb	SE	t	p
		0.04	1.20
FTO1 rs9939609 (A/A or T/A = 8/13)c				0.10	15.53	0.37	0.72
Frontostriatal circuit				0.18	14.72	0.64	0.54
Other regions				−0.46	19.00	−1.65	0.13

R= right

^aAdjusted R2

^bStandardized b

^cFTO rs9939609. Coded with A/A as the reference group. A/A and T/A = 0, T/T = 1. We report the number of participants with A/A or T/A out of the total number of participants analyzed.

% Weight in Kg lost = [(Weight in kg at later assessment time – Weight in Kg at baseline)/ baseline BMI] * 100%.