Table 3.
Pearson correlations between vaping behavior variables and nicotine delivery and nicotine pharmacokinetics during 90 minutes of ad libitum access to e-cigarettes
| Number of puffs taken | Total puffing time (s) | Average puff duration (s) | Average interpuff interval (s) | |
|---|---|---|---|---|
| A. All subjects, users of cartridges, tanks, and RBAs (n = 13) | ||||
| E-liquid nicotine (ug/mg) | 0.26 (0.38) | 0.20 (0.51) | −0.03 (0.93) | 0.18 (0.55) |
| E-liquid vaped (mg) | 0.09 (0.76) | −0.02 (0.94) | −0.27 (0.37) | −0.20 (0.51) |
| Nicotine inhaled (mg) | 0.36 (0.23) | 0.16 (0.60) | −0.35 (0.24) | −0.32 (0.29) |
| Cmax (ng/mL) | 0.24 (0.43) | 0.11 (0.72) | −0.31 (0.31) | −0.35 (0.25) |
| Tmax (min) | 0.29 (0.33) | 0.32 (0.29) | 0.02 (0.95) | 0.29 (0.33) |
| AUC0→90 | 0.31 (0.30) | 0.14 (0.64) | −0.35 (0.24) | −0.40 (0.18) |
| B. Users with tanks only (n = 8) | ||||
| E-liquid nicotine (ug/mg) | 0.29 (0.49) | −0.15 (0.72) | −0.48 (0.23) | −0.18 (0.67) |
| E-liquid vaped (mg) | 0.66 (0.08) | 0.64 (0.09) | −0.26 (0.54) | −0.62 (0.10) |
| Nicotine inhaled (mg) | 0.74 (0.04) | 0.39 (0.33) | −0.48 (0.23) | −0.60 (0.11) |
| Cmax (ng/mL) | 0.77 (0.02) | 0.48 (0.23) | −0.55 (0.16) | −0.69 (0.06) |
| Tmax (min) | 0.42 (0.30) | 0.31 (0.45) | −0.08 (0.85) | −0.25 (0.56) |
| AUC0→90 (ng/mL min) | 0.85 (0.008) | 0.55 (0.16) | −0.54 (0.16) | −0.74 (0.04) |
Note: Tmax, time to maximum plasma nicotine concentration; Cmax, maximum plasma nicotine concentration; AUC0→90, area under the plasma nicotine concentration time curve from 0 to 90 minutes; RBA is rebuildable atomizer; p-values shown in parentheses.