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. 2017 Feb 14;23(1):66–73. doi: 10.3350/cmh.2016.0060

Table 4.

Univariate and multivariate analyses of factors associated with complete virologic suppression in 99 HBeAg-positive patients

Variables Univariate analysis
Multivariate analysis
HR (95% CI) P-value HR (95% CI) P-value
Age 1.01 (1.00-1.01) 0.59
Gender (male vs. female) 0.90 (0.57-1.41) 0.64
Presence of cirrhosis 0.96 (0.62-1.51) 0.87
Baseline HBV DNA (log10 IU/mL) 0.88 (0.77-1.00) 0.06 0.82 (0.71-0.95) 0.007
High baseline ALT level (above ULN) 0.93 (0.51-1.68) 0.80
Baseline serum creatinine (mg/dL) 0.33 (0.09-1.25) 0.10 0.33 (0.07-1.01) 0.07
Previous treatment
 NA-naïve 1.00 (reference) 1.00 (reference)
 NA except ADV- experienced 1.08 (0.64-1.82) 0.77 0.83 (0.47-1.45) 0.51
 ADV experienced 0.47 (0.21-1.04) 0.06 0.28 (0.12-0.66) 0.004

HBeAg, hepatitis B antigen; HR, hazard ratio; CI, confidence interval; HBV, hepatitis B virus; ALT, alanine aminotransferase; ULN, upper limit of normal; NA, nucleos(t)ide analogue; ADV, adefovir.