Table 4.
Variables | Univariate analysis |
Multivariate analysis |
||
---|---|---|---|---|
HR (95% CI) | P-value | HR (95% CI) | P-value | |
Age | 1.01 (1.00-1.01) | 0.59 | ||
Gender (male vs. female) | 0.90 (0.57-1.41) | 0.64 | ||
Presence of cirrhosis | 0.96 (0.62-1.51) | 0.87 | ||
Baseline HBV DNA (log10 IU/mL) | 0.88 (0.77-1.00) | 0.06 | 0.82 (0.71-0.95) | 0.007 |
High baseline ALT level (above ULN) | 0.93 (0.51-1.68) | 0.80 | ||
Baseline serum creatinine (mg/dL) | 0.33 (0.09-1.25) | 0.10 | 0.33 (0.07-1.01) | 0.07 |
Previous treatment | ||||
NA-naïve | 1.00 (reference) | 1.00 (reference) | ||
NA except ADV- experienced | 1.08 (0.64-1.82) | 0.77 | 0.83 (0.47-1.45) | 0.51 |
ADV experienced | 0.47 (0.21-1.04) | 0.06 | 0.28 (0.12-0.66) | 0.004 |
HBeAg, hepatitis B antigen; HR, hazard ratio; CI, confidence interval; HBV, hepatitis B virus; ALT, alanine aminotransferase; ULN, upper limit of normal; NA, nucleos(t)ide analogue; ADV, adefovir.