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. 2017 Apr 5;12(4):e0174181. doi: 10.1371/journal.pone.0174181

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© 2017 Chang et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 3 — hSC-CMs were plated out at low density and exposed to clinically relevant doses of known small molecule inhibitors of the sodium channel NaV1.5 (flecainide 0.5μM), the potassium channel KCNH2/hERG (dofetilide, 5nM, and cisapride, 30nM), and the voltage gated calcium channel CACNA1.2 (nifedipine, 100nM; verapamil 1μM, diltiazem 1μM). Traces obtained at 0.3Hz, and 0.6Hz are shown for the annotated small molecule as before with the average response shown by the thick line. Analysis of the data is presented in Tables 1 and 2.