Table 1. 0.3Hz hSC-CM stimulation results following drug addition summary.
CTD50 (s) | CTD90 (s) | Calcium change (%) | Rising Slope | Decay time τ (s) | |
---|---|---|---|---|---|
Baseline | 0.32+-0.09 | 0.54+-0.18 | 38.12+-12.96 | 1.53+-0.47 | 0.16+-0.04 |
Flecainide (0.5 μM) | 0.79+-0.07** | 1.32+-0.34** | 37.28+-17.13 | 0.72+-0.34* | 0.30+-0.01** |
Dofetilide (5nM) | 0.34+-0.05 | 0.69+-0.11* | 23.83+-8.59 | 1.03+-0.41* | 0.18+-0.01* |
Cisapride (30nM) | 0.50+-0.14 | 0.97+-0.31** | 32.56+-6.21 | 2.08+-1.10 | 0.31+-0.06* |
Nifedipine (100nM) | 0.23+-0.06** | 0.50+-0.11 | 7.53+-0.44** | - | 0.22+-0.04* |
Significance values are indicated by
P = <0.05*,
P<0.005**