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. 2017 Apr 1;353(1):46–53. doi: 10.1016/j.yexcr.2017.03.005

Fig. 3.

Fig. 3.

CHIP-CD166 axis in the regulation of cancer stem-like properties of HNC cells. (A) Colony formation capacity of HN13-shCD166 cells compared with HN13-Control cells (**p=0.006). (B) Microsphere formation ability of HN13-shCD166 cells compared with HN13-Control cells (**p=0.003). (C) Western blotting results showed CD166 and CHIP expression levels in HN13-Control cells transfected with Scrambled siRNA seqeuence and in HN13-shCD166 cells transfected with Scrambled and two pair of CHIP specific siRNA sequences. Colony forming and miscrosphere forming abilities were detected and compared under the indicated treatment (**p<0.01). (D) Western blot results showed CD166 and CHIP expression levels in UMSCC12-Control cells transfected with Scrambled siRNA seqeuence and in UMSCC12-shCHIP cells transfected with Scrambled and two pair of CD166 specific siRNA sequences. Colony forming and miscrosphere forming abilities were detected and compared under the indicated treatment (**p<0.01).