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. 2016 Nov 4;125(4):691–698. doi: 10.1289/EHP291

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Metabolic scheme of targeted oxylipins. Oxylipin synthesis via different biosynthetic pathways, COX, 5-LOX, 12/15-LOX, and CYP from their corresponding precursor fatty acids, arachidonic acid, eicosapentaenoic acid, dihomo-γ-linolenic acid, and linoleic acid (Zivkovic et al. 2012). All shown metabolites were targeted except for 5-HPETE (5-hydroperoxy-eicosatetraenoic acid), LTA₄ (Leukotriene A4), and PGH₂ (prostaglandin H2) and classified by biosynthetic pathway. Nondetectable targeted oxylipins (17-HDoDE, Resolvin D1, and Resolvin D2) are not shown on the scheme. A list of full metabolite names is provided in Table S4.