Agnostic approaches are encouraged for detection of emerging exposures of concern Techniques (and development of techniques) promote identification of unknown/emerging exposures of concern Links exogenous exposures to internal biochemical perturbations A large number of features can be detected (> 10,000) for the cost of a single traditional biomonitoring analysis Includes biomolecular reaction products (e.g., protein adducts, DNA adducts) for which traditional biomonitoring measurements are often lacking or cumbersome Requires a small amount of biologic specimen (~ 100 μL or less) for full-suite analysis Enables detection of “features” that are linked to exposure or disease for further confirmation Encourages techniques to capture short-lived chemicals Aims to measure biologically meaningful lifetime exposures, both exogenous and endogenous, of health relevance
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Agnostic approach can be problematic for grant funding May not detect chemicals present at low levels Cannot detect all analytes present in chemical space A reference or baseline value may not be possible to define Extensive bioinformatics required for data reduction/analysis Requires carefully collected and well-maintained biospecimens Can only measure chemicals that are isolated in extraction process (e.g., acetonitrile extraction would not necessarily capture lipophilic chemicals) Relies heavily upon library searching of spectra for annotation with standard confirmation coming later, which can be quite time-consuming and labor-intensive May be difficult to link measures to exposure source Includes lifetime exposures but does not place enough emphasis on defining and measuring windows of susceptibility (e.g., in utero) to accurately capture the most biologically important exposures
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