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. Author manuscript; available in PMC: 2018 Apr 1.
Published in final edited form as: Biol Blood Marrow Transplant. 2017 Jan 10;23(4):618–624. doi: 10.1016/j.bbmt.2017.01.067

Table 1.

Dose Levels for dose escalation of TMLI in TMLI/CY/VP16 alloHSCT conditioning regimen.

Level # Patients Fraction and Schedule Total Dose
1 3 150 cGy bid × Days 1–4 1200 cGy
2 3 150 cGy bid Day 1–4,150 cGy qd Day 5 1350 cGy
3 9 150 cGy bid Days 1–5 1500 cGy (ribs, sternum, liver, brain limited to 1200cGy)
4 6 150 cGy bid Days 1–5 1500 cGy (liver, porta hepatis, brain limited to 1200cGy)
5 6 160 cGy bid Days 1–5 1600 cGy (liver, porta hepatis, brain limited to 1200cGy)
6 6 170 cGy bid Days 1–5 1700 cGy (liver, porta hepatis, brain limited to 1200cGy)
7 6 180 cGy bid Days 1–5 1800 cGy (liver, porta hepatis, brain limited to 1200cGy)
8 6 190 cGy bid Days 1–5 1900 cGy (liver, porta hepatis, brain limited to 1200cGy)
9 6 200 cGy bid Days 1–5 2000 cGy (liver, porta hepatis, brain limited to 1200cGy)