Table 2.
Patient and disease characteristics.
| Variable | Median (range) or N |
|---|---|
| Age at transplant (years) | 34 (16–57) |
|
| |
| Disease diagnosis | |
| AML | 33 |
| ALL Ph− | 14 |
| ALL Ph+ | 2 |
| biphenotypic | 1 |
| undifferentiated | 1 |
|
| |
| Disease status at time of alloHSCT | |
| 1 RL | 14 |
| 2 RL | 3 |
| IF | 34 |
|
| |
| Cytogenetic risk (SWOG criteria), AML | |
| favorable | 0 |
| intermediate | 19 |
| unfavorable | 14 |
|
| |
| Cytogenetic risk (SWOG criteria), ALL | |
| favorable | 1 |
| intermediate | 7 |
| unfavorable | 5 |
| unknown significance | 3 |
|
| |
| Risk score* | 3 (0–6) |
|
| |
| KPS at HSCT | 80 (60–100) |
|
| |
| Donor source | |
| sibling | 25 |
| HLA matched unrelated | 5 |
| mismatched (1 allele) unrelated | 21 |
|
| |
| WBC at HSCT | 1.4 (0.1–14.9) |
|
| |
| % Blasts in blood at transplant** | 5 (0–85) |
|
| |
| % Blasts in marrow at transplant** | 52 (5–98) |
|
| |
| Extramedullary disease at time of HSCT | 9 |
AML=acute myeloid leukemia, ALL=acute lymphoblastic leukemia, Ph=Philadelphia chromosome, alloHSCT=allogeneic hematopoietic stem cell transplantation, RL=relapse, IF=induction failure, KPS=Karnofsky Performance Status, HLA=human leukocyte antigen, WBC=white blood cell count.
Scoring based on criteria by Duval et al.1
Excludes patients with solely extramedullary disease (Blasts in BM < 5%), n=4