Table 2.
Patient and disease characteristics.
Variable | Median (range) or N |
---|---|
Age at transplant (years) | 34 (16–57) |
| |
Disease diagnosis | |
AML | 33 |
ALL Ph− | 14 |
ALL Ph+ | 2 |
biphenotypic | 1 |
undifferentiated | 1 |
| |
Disease status at time of alloHSCT | |
1 RL | 14 |
2 RL | 3 |
IF | 34 |
| |
Cytogenetic risk (SWOG criteria), AML | |
favorable | 0 |
intermediate | 19 |
unfavorable | 14 |
| |
Cytogenetic risk (SWOG criteria), ALL | |
favorable | 1 |
intermediate | 7 |
unfavorable | 5 |
unknown significance | 3 |
| |
Risk score* | 3 (0–6) |
| |
KPS at HSCT | 80 (60–100) |
| |
Donor source | |
sibling | 25 |
HLA matched unrelated | 5 |
mismatched (1 allele) unrelated | 21 |
| |
WBC at HSCT | 1.4 (0.1–14.9) |
| |
% Blasts in blood at transplant** | 5 (0–85) |
| |
% Blasts in marrow at transplant** | 52 (5–98) |
| |
Extramedullary disease at time of HSCT | 9 |
AML=acute myeloid leukemia, ALL=acute lymphoblastic leukemia, Ph=Philadelphia chromosome, alloHSCT=allogeneic hematopoietic stem cell transplantation, RL=relapse, IF=induction failure, KPS=Karnofsky Performance Status, HLA=human leukocyte antigen, WBC=white blood cell count.
Scoring based on criteria by Duval et al.1
Excludes patients with solely extramedullary disease (Blasts in BM < 5%), n=4