Table 4.

Toxicities by dose level.

Organ Assessed	DL1 (n=3) 1200 cGy		DL2 (n=3) 1350 cGy		DL3 (n=9) 1500 cGy		DL4 (n=6) 1500 cGy			DL5 (n=6) 1600 cGy		DL6 (n=6) 1700 cGy		DL7 (n=6) 1800 cGy		DL8 (n=6) 1900 cGy		DL9 lead-in (n=6) 2000 cGy
	Grade		Grade		Grade		Grade			Grade		Grade		Grade		Grade		Grade
	1	2	1	2	1	2	1	2	3	1	2	1	2	1	2	1	2	1	2	3
Bladder toxicity	0	0	0	0	0	0	1	0	0	0	1	0	0	0	1	1	0	0	0	0
Cardiac toxicity	0	0	0	0	2	1	2	1	0	1	0	1	0	1	1	1	0	0	0	0
CNS toxicity	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	2	0	0
GI toxicity	2	0	3	0	6	0	3	0	0	5	1	1	1	6	0	5	0	4	2	0
Hepatic toxicity	0	0	0	1	0	3	1	1	0	1	0	0	0	0	0	0	1	0	0	0
Pulmonary toxicity	0	0	0	0	2	0	0	0	1	0	0	2	0	0	0	1	1	0	0	0
Renal toxicity	0	0	0	0	0	0	1	0	1	0	0	0	1	0	0	0	0	0	0	1**
Stomatitis	2	0	1	0	1	7	2	3	1*	3	1	0	0	0	0	1	3	0	1	0

^*This patient had the only dose-limiting toxicity in the trial.

^**Renal failure was secondary to septic shock secondary to infection not related to the conditioning regimen and therefore not considered a DLT.