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. 2017 Mar 23;49(1):10–21. doi: 10.3947/ic.2017.49.1.10

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Copyright © 2017 by The Korean Society of Infectious Diseases and Korean Society for Chemotherapy

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Neutrophils anti-microbial action is linked to bioenergetics

NADPH, which is required for production of ROS, is generated in PPP branch of glycolysis or from the oxidation of glutamine derived malate to pyruvate. In this manner, the biochemical pathways of glycolysis and glutaminolysis provide the microbicidal activity to activated neutrophil.

PPP, pentose phosphate pathway; ADP, adenosine diphosphate; ATP, adenosine triphosphate; ROS, reactive oxygen species; MPO myeloperoxidase; NOX2, NADPH oxidase 2; HOCI, hypochlorous acid.