Table 4. Risk factors related to mortality in Community-acquired acute pyelonephritis.
| Characteristics | Hospital mortality (n = 12) | Final clinical failure (n = 38) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Univariate | Multivariate | Univariate | Multivariate | |||||||
| N (%) | OR (95% CI) | P-value | OR (95% CI) | P-value | N (%) | OR (95% CI) | P-value | OR (95% CI) | P-value | |
| Age ≥70 years | 8 (66.7) | 5.038 (1.501-16.912) | 0.007 | 17 (44.7) | 2.062 (1.066-3.991) | 0.029 | ||||
| Co-morbidities | ||||||||||
| Charlson comorbidity index ≥1 | 9 (75.0) | 4.521 (1.214-16.838) | 0.018 | 3.964 (0.817-19.229) | 0.087 | 26 (68.4) | 3.396 (1.685-6.842) | <0.001 | 3.909 (1.610-9.493) | 0.003 |
| Diabetes mellitus | 4 (33.3) | 1.406 (0.419-4.723) | 0.526 | 14 (36.8) | 1.679 (0.851-3.316) | 0.132 | ||||
| Chronic renal disease | 1 (8.3) | 1.532 (0.193-12.157) | 0.505 | 6 (15.8) | 3.490 (1.371-8.882) | 0.005 | ||||
| Laboratory findings | ||||||||||
| WBC ≥20,000/mm3 | 5 (41.7) | 6.863 (2.121-22.205) | 0.004 | 11 (28.9) | 4.158 (1.969-8.779) | <0.001 | 3.472 (1.406-8.574) | 0.007 | ||
| CRP ≥20 mg/dl | 3 (25.0) | 0.812 (0.218-3.029) | 1.000 | 15 (39.5) | 1.639 (0.839-3.204) | 0.145 | ||||
| Positive blood culture | 9/10 (90.0) | 12.533 (1.577-99.578) | 0.003 | 9.290 (1.145-75.392) | 0.037 | 20/29 (69.0) | 3.165 (1.416-7.076) | 0.003 | ||
| Discordant therapya | 1 (8.3) | 1.325 (0.167-10.483) | 0.554 | 12 (31.6) | 1.770 (0.872-3.593) | 0.110 | 2.217 (1.001-4.912) | 0.050 | ||
a Discordant therapy was defined as cases whose empirical antimicrobial therapy regimen was changed due to the drug resistance.
OR, odds ratio; CI, confidence interval; WBC, white blood cell; CRP, C-reactive protein.