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. Author manuscript; available in PMC: 2018 Apr 1.
Published in final edited form as: Mol Inform. 2016 Dec 21;36(4):10.1002/minf.201600126. doi: 10.1002/minf.201600126

Table 1.

The 31 drugs tested by the patch-clamp assay (“Patch-Clamp”) and the thallium flux assay (“Flux”). The threshold to separate hERG active from inactive drugs is set to 30 µM, or pIC50 of 4.52.

ID Name pIC50 Patch-Clamp Flux Concordance ID Name pIC50 Patch-Clamp Flux Concordance
42 Ofloxacin 2.85 N N 1 60 Flecainide 5.41 P P 1
11 Ciprofloxacin 3.02 N N 1 30 Imipramine 5.47 P P 1
68 Trimethoprim 3.62 N N 1 61 Fluoxetine 5.82 P P 1
25 Gatifloxacin 3.89 N N 1 10 Chlorpromazine 5.83 P P 1
24 Epinastine 4.00 N P 0 35 Mibefradil 5.84 P P 1
20 Disopyramide 4.04 N P 0 53 Thioridazine 6.44 P P 1
26 Grepafloxacin 4.30 N N 1 46 Quinidine 6.49 P P 1
39 Nifedipine 4.30 N N 1 51 Terfenadine 6.70 P P 1
19 Diphenhydramine 4.57 P P 1 66 Olanzapine 6.74 P N 0
18 Diltiazem 4.76 P N 0 47 Risperidone 6.82 P P 1
7 Carvedilol 4.98 P P 1 54 Verapamil 6.85 P P 1
2 Amiodarone 5.00 P P 1 45 Pimozide 7.30 P P 1
40 Nitrendipine 5.00 P N 0 59 Droperidol 7.49 P P 1
44 Perhexiline 5.11 P P 1 28 Haloperidol 7.52 P P 1
64 Mefloquine 5.25 P P 1 4 Astemizole 8.00 P P 1
21 Dofetilide 8.00 P P 1