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. Author manuscript; available in PMC: 2017 Apr 14.
Published in final edited form as: Leukemia. 2016 Oct 14;31(4):872–881. doi: 10.1038/leu.2016.282

Figure 2. Dynamic changes in mutation VAFs during treatment.

Figure 2

Mutation variant allele fraction (VAF) in paired pre-study and time of best response samples from patients that achieved a complete remission (a) versus those that did not (b and c) (left panels). Each line represents a mutation that occurred in a diploid part of the genome. Serial mutation VAFs are displayed in the right panel. Stable disease (SD, n=2, blue), marrow leukemia free state (mLFS, n=2, orange), or marrow complete remission (mCR, n=2, orange). VAF, variant allele fraction.