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. Author manuscript; available in PMC: 2017 May 12.
Published in final edited form as: Genet Med. 2016 Oct 6;19(5):599–603. doi: 10.1038/gim.2016.147

Table 1.

Breast cancer risk associated with the polygenic risk score (PRS) for non-carriers and the carriers of CHEK2*1100delC.

Non-carriers CHEK2*1100delC carriers
OR [95% CI] P OR [95% CI] P
PRSa 1.58 [1.55 – 1.62] <1.0E-10 1.59 [1.21 – 2.09]b 0.0008
Percentile of PRS, %
< 20 0.52 [0.48 – 0.56] <1.0E-10 0.52 [0.16 – 1.74] 0.29
20–40 0.78 [0.72 – 0.84] 2E-11 0.72 [0.28 – 1.88] 0.51
40–60 referent referent
60–80 1.25 [1.16 – 1.34] 8E-10 0.93 [0.39 – 2.25] 0.88
> 80 1.92 [1.80 – 2.06] <1.0E-10 2.03 [0.86 – 4.78] 0.11
a

Odds ratio (OR) was estimated per unit standard deviation of the PRS.

b

P-value for pairwise interaction between CHEK2*1100delC and PRS: 0.93.