. Author manuscript; available in PMC: 2017 May 12.

Published in final edited form as: Genet Med. 2016 Oct 6;19(5):599–603. doi: 10.1038/gim.2016.147

Table 2.

Relative breast cancer risk associated with CHEK2*1100delC, PRS and positive family history of breast cancer in the analysis data set.

Risk model	Parameters	OR [95% CI]	P
BC ~ 1100delC + PRS	1100delC	2.99 [2.32 – 3.85]	<1.0E-10
BC ~ 1100delC + PRS	PRS	1.58 [1.55 – 1.62]	<1.0E-10
BC ~ 1100delC + PRS + family history	1100delC	2.42 [1.71 – 3.47]	9.4E-7
	PRS	1.55 [1.50 – 1.60]	<1.0E-10
	family history^a	2.73 [2.48 – 3.47]	<1.0E-10

No significant interaction between positive family history of breast cancer and either CHEK2*1100delC or PRS was found.