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. Author manuscript; available in PMC: 2017 Apr 24.
Published in final edited form as: Leukemia. 2016 Oct 24;31(4):853–860. doi: 10.1038/leu.2016.296

Figure 1. LIN28B expression level in MM.

Figure 1

LIN28B expression level in MM patients, compared to healthy individuals, by analysis of (a) Left panel: GSE16558 (5 normal donor plasma cells and 65 plasma cell samples from patients with newly diagnosed MM) and right panel: GSE24080 – containing 22 normal donor plasma cell samples - and GSE2658 – 559 plasma cell samples from patients with newly diagnosed patients - both from UAMS, which were normalized using GeneSpring. (b) Kaplan-Meier analysis of 542 patients with MM of the Total Therapy 2 cohort (GSE2658). Patients were classified as high vs. low expression of LIN28B based on the mean expression level. LIN28B was associated with significantly worse overall survival, (p=0.0075). (c) MOLP-8, KMS12BM, RPMI 8226 and KMM-1 cells infected with control shRNA, or 2 different LIN28B shRNAs, were studied for relative expression of LIN28B mRNA as determined by qRT-PCR.