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. Author manuscript; available in PMC: 2017 Apr 24.
Published in final edited form as: Leukemia. 2016 Oct 24;31(4):853–860. doi: 10.1038/leu.2016.296

Figure 3. The LIN28B/let-7 axis in data sets and in vivo.

Figure 3

(a) GSEA analysis showing an enrichment of let-7 target genes in MM patients who display a high level of LIN28B expression in two independent datasets (GSE2658 and MMRC dataset). (b) Tumor volume and (c) survival of SCID/bg mice (5 per group) injected subcutaneously with 5.106 MOLP-8 cells expressing pLKO control shRNA or pLKO.LIN28BshRNA; average survival time was 26 days versus 33 days, respectively, P = 0.0045. Bars indicate mean ± SD (n = 3).