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. Author manuscript; available in PMC: 2017 Apr 24.
Published in final edited form as: Leukemia. 2016 Oct 24;31(4):853–860. doi: 10.1038/leu.2016.296

Figure 7. Let-7 is down-regulated in MM and regulates MYC.

Figure 7

(a) qRT-PCR analysis of let-7 family members in primary plasma cells from healthy donors and MM patients, as well as in 4 MM cell lines. (b) proliferation assay using thymidine uptake and 72 hours after transfection of a let-7b mimic or a control probe in MM.1S cells. Bars indicate mean ± SD (n = 3). P values were obtained by two-tailed Student t test (*P < 0.05). (c) Correlation between let-7 and MYC expression in patients with MM. Scatter plot showing the correlation between let-7b and g, respectively, and MYC from GSE16558. A Pearson correlation coefficient and a two-tailed p value were computed for each of them.