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Chaperone-mediated degradation of misfolded proteins. CMA is a selective proteolytic system in which cytosolic proteins carrying the KFERQ pentapeptide are targeted by Hsc70. The function of Hsc70 requires cochaperones, such as Hsp40, Hsp90, HIP, HOP, and BAG-1. The substrates associated with the Hsc70 chaperone system are translocated to the lysosomal membrane through the interaction of Hsc70 with LAMP2A, a single-span membrane protein. L2A, LAMP2A.
