Figure 5.

Signalling pathways regulated by PrP^C. Various downstream signalling pathways are reportedly modulated as a result of PrP^C interacting with specific co-receptors (some candidate co-receptors are included in Table 2). Cellular functions regulated by these pathways are shown in italics. Arrows indicate positive regulation, inhibition is shown by the flat-ended lines, and connectors without arrows indicate that the direction of regulation may be context-specific. Dotted lines represent crosstalk between pathways; therefore, some of the pathways shown may be regulated indirectly through other pathways rather than modulated directly by PrP^C. SFK, Src family kinase, which includes Fyn kinase.