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. 2017 Mar 1;34(5):890–917. doi: 10.1007/s11095-017-2129-z

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© The Author(s) 2017

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 11 — Quantitative analysis of tablet disintegration by MRI. (a) shows the MRI data, which is binarised using a threshold image intensity. Subsequently the edges are detected as depicted in (b), which is used for the calculation of the fractal dimension. This procedure was applied on MRI measurements of tablets with different disintegrants and analysed as a function of time as depicted in (c). SSG I: sodium starch glycolate (Explotab); SSG II: sodium starch glycolate (Primojel); PP I: polacrilin potassiumPolacrilin potassium (Amberlite IRP88); PP II: polacrilin potassium (Kyron T-314); XPVP: crospovidone (Polyplasdone XL), CCS: croscarmellose sodium (Ac-Di-Sol); DCP: dibasic calcium phosphateDibasic calcium phosphate (Di-Cafos C92-14) (modified from [131]).