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. 2017 Apr 3;8:14883. doi: 10.1038/ncomms14883

Figure 6. Biocatalytic formation of spiro-1,1′-disubstituted THIQs using Δ29TfNCS variants.

Figure 6

(a) Spiro-THIQ products isolated from biotransformations. All compounds feature a fixed stereocentre at the C-4 position. (b) Chiral (R)-Spiro-THIQ product (1R,3R)-17 isolated from biotransformation. Important NOE (nuclear Overhauser effect) correlations are highlighted. See Supplementary Methods for full synthetic procedures, Supplementary Figs 9 and 10 for HPLC analysis and Supplementary Figs 14-18 for NMR spectra.