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. 2017 Apr 3;8:14883. doi: 10.1038/ncomms14883

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Copyright © 2017, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(a) Spiro-THIQ products isolated from biotransformations. All compounds feature a fixed stereocentre at the C-4 position. (b) Chiral (R)-Spiro-THIQ product (1R,3R)-17 isolated from biotransformation. Important NOE (nuclear Overhauser effect) correlations are highlighted. See Supplementary Methods for full synthetic procedures, Supplementary Figs 9 and 10 for HPLC analysis and Supplementary Figs 14-18 for NMR spectra.