Table 1.
Patient characteristics of the head and neck cancers for which DNA methylome data were analysed
| Patient characteristics | HPV positive No. cases (%)a | HPV negative No. cases (%)a |
|---|---|---|
| Pooled cases | 66 (100) | 272 (100) |
| TCGA | 36 (54.5) | 242 (89.0) |
| UCL | 24 (21 FFPE) (36.4) | 24 (21 FFPE (8.8) |
| FITMANET | 6 (9.1) | 6 (2.2) |
| Male | 55 (83.3) | 195 (71.7) |
| Female | 11 (17.7) | 77 (28.3) |
| Median age (range) | 59 (35–86) | 62 (19–90) |
| Tobacco smoking | ||
| Never/light smokers | 17 (25.7) | 54 (19.8) |
| Smokers | 25 (37.9) | 218 (80.0) |
| Not available | 24 (36.4) | 25 (9.2) |
| Alcohol consumption | ||
| No | 9 (13.6) | 83 (30.5) |
| Yes | 32 (48.5) | 159 (58.5) |
| Not available | 25 (37.9) | 30 (11.0) |
| Tumour stage | ||
| T1 | 8 (12.1) | 13 (4.8) |
| T2 | 19 (28.8) | 49 (18.0) |
| T3 | 9 (13.6) | 64 (23.5) |
| T4 (A + B) | 28 (42.4) | 118 (43.4) |
| Not available | 2 (3.1) | 28 (10.3) |
| Tumour site | ||
| Oral cavity | 12 (18.2)b | 162 (59.5) |
| Oropharynx | 51 (77.3)c | 35 (12.9) |
| Neck (hypopharynx and larynx) | 3 (4.5)d | 75 (27.6) |
aPercentage calculated using the total number of cases in the group of reference
bHPV16: 8 cases, HPV33: 4 cases
cHPV16: 48 cases, HPV33: 3 cases (1 co-infection with HPV16), HPV35: 1 case
dHPV16: 3 cases (2 cases in hypopharynx, 1 case in larynx)