Table 3.
Unadjusted and adjusted effects of PAPP-A
| All (n = 320) | T2DM (−) (n = 184) | T2DM (+) (n = 136) | ||||
|---|---|---|---|---|---|---|
| HR (95% CI)* | % Δ** (%) | HR (95% CI)* | % Δ** (%) | HR (95% CI)* | %Δ** (%) | |
| Unadjusted | 3.10 (2.48–3.87) | 0 | 3.16 (2.27–4.39) | 0 | 2.97 (2.11–4.18) | 0 |
| Adjusted for | ||||||
| Age | 2.93 (2.34–3.66) | −5 | 3.04 (2.14–4.32) | −4 | 3.16 (2.21–4.53) | 6 |
| Sex | 3.05 (2.44–3.82) | −1 | 3.36 (2.36–4.79) | 7 | 3.04 (2.14–4.31) | 2 |
| LVEF (%) | 3.02 (2.41–3.79) | −3 | 2.96 (2.11–4.17) | −6 | 2.97 (2.11–4.19) | 0 |
| HbA1C | 3.06 (2.43–3.86) | −1 | 3.18 (2.23–4.55) | 1 | 2.98 (2.11–4.19) | 0 |
| Troponin I | 3.09 (2.46–3.88) | 0 | 3.18 (2.27–4.45) | 1 | 2.89 (2.05–4.07) | −3 |
| hsCRP | 2.86 (2.21–3.69) | −8 | 2.95 (2.02–4.30) | −7 | 2.79 (1.88–4.13) | −6 |
HR for 1 SD increase in log10 PAPP-A for single covariates. All adjusted HRs for PAPP-A are adjusted for the single variable that is specified
* p < 0.001 for all variables
** Percent change in HR compared to the unadjusted HR