Table 4.

The significant exercise-regulated molecular pathways identified fallowing training in Arabian horses

Pathway	Kegg number	Gene N	Gene symbol	p	Gene N	Gene symbol	p	Gene N	Gene symbol	p
Comparison		T1 vs T2			T2 vs T3			T0 vs T3
Jak-STAT signaling pathway	ecb04630				4	BCL2, IL6ST, PIK3CG, PTPN11,	0.03	6	BCL2, CCND2, IL6ST, IL7R, PIK3CG, PTPN11,	0.01
PI3K-Akt signaling pathway	ecb04151				6	BCL2, FOXO3, GNBa, ITGA4, PIK3AP1, PIK3CG,	0.01	11	BCL2, CCND2, FOXO3, GNB4, IL7R, ITGA4, PIK3AP1, PIK3CG, PPP2R5E, YWHAG, GNGT2	0.001
cAMP signaling pathway	ecb04024				2	PDE3B, PIK3CG	0.04	7	ATP2B, CAMK4, NFATC1, PDE3B, PDE4A, PIK3CG, PPP1R12A	0.003
FoxO signaling pathway	ecb04068				4	ATM, FOXO3, PIK3CG, TGFBR1,	0.03	8	ATM, CCND2, FOXO3, IL7R, STK4, PIK3CG, S1PR4, TGFBR1	0.001
Glycerophospholipid metabolism	ecb00564	4	AGPAT5, LGPAT1, GPD1, PLA2G4F	0.001	4	AGPAT3, AGPAT5, GPD2, LPGAT1,	0.01	5	AGPAT3, AGPAT5, GPD2, LPGAT1, PCYT1A	0.002
Insulin signaling pathway	ecb04910				4	CBL, CBLB, PDE3B, PIK3CG	0.02	5	CBL, FASN, CBLB, PDE3B, PIK3CG	0.02
Calcium signaling pathway	ecb04020	2	CYSLTR1, SLC25A4	0.01	3	ITPR1, ITPR2, CYSLTR1	0.03	5	ATP2A2, ATP2B4, CAMK4, ITPR1, ITPR2,	0.03
Regulation of actin cytoskeleton	ecb04810	1	MYLPF	ns	6	ARHGEF6, IQGAP2, ITGA4, PAK2, PIK3CG, SSH2,	0.01	8	ARHGEF6, IQGAP2, ITGA4, MSN, PAK2, PIK3CG, SSH2, PPP1R12A	0.02
Notch signaling pathway	ecb04330				2	KAT2B, RBPJ	ns	5	KAT2B, NCOR2, NOTCH1, NOTCH2, RBPJ	0.001
Hypertrophic cardiomyopathy (HCM)	ecb05410	4	CACNB1, TPM1, TPM2, TTN,	0.03	1	ITGA4	ns	1	ITGA4	ns

N number of identified genes, ns not significant; gene symbol indicated in bold were identified as down-regulated during training periods