Relationship between the percent change in eGFR from baseline to 72 hours and the composite outcome of death, rehospitalization, or emergency room visit within 60 days in patients admitted with acute decompensated heart failure and enrolled in a clinical trial of diuretic strategies. The solid blue line represents a hazard ratio of 1. CI: confidence interval; eGFR: estimated glomerular filtration rate; ER: emergency room. Reproduced with permission from Brisco MA, Zile MR, Hanberg JS, Wilson FP, Parikh CR, Coca SG, Tang WH and Testani JM. Relevance of Changes in Serum Creatinine During a Heart Failure Trial of Decongestive Strategies: Insights From the DOSE Trial. J Card Fail. 2016;22:753–60.19