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Number of nonsynonymous (amino acid) substitutions observed as a function of the number of nonsynonymous (amino acid) mutation trials for local-score and global-score SCPE simulations. Results are averaged over 300 independent runs. Note that global-score simulations present a definite change in slope (acceptance rate ω) between the first steps of the simulations and longer times. In contrast, local-score simulations present a constant slope (acceptance rate ω).
