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Effect of alectinib on the expression levels of ABCB1 or ABCG2 in MDR cells. The protein levels of ABCB1 and ABCG2 were detected by western blot (a, b). Real-time PCR assay was performed to quantify the mRNA levels of ABCB1 and ABCG2 in the MDR cells (c, d). The cell surface expression of ABCB1 or ABCG2 in KBv200 or S1-MI-80 cells, respectively, was detected by flow cytometry (e, f). Representative results from three independent experiments are shown in a, b, e and f, respectively.
