. 2017 Mar 24;49(3):e309. doi: 10.1038/emm.2017.21

Table 2. Toxicokinetic parameters on days 1 and 22 following intravenous infusion of YYB-101 at 10, 50, or 200 mg kg⁻¹ perday in cynomolgus monkeys (males and females combined).

Dose (mg kg⁻¹ day⁻¹)	Day	Statistic	C_max (ng ml⁻¹)	C_max/Dose (kg × ng ml⁻¹ mg⁻¹)	T_maxa(h)	T_lasta(h)	AUC_Tlast (ng × h ml⁻¹)	AUC_0-168hr (ng × h ml⁻¹)	AUC_0-168hr/Dose (kg × ng × h ml⁻¹ mg⁻¹)	Rb
10	1	N	6	6	2 (2–2)	168 (168–168)	6	6	6	NA
		Mean	363 000	3 6300			31 000 000	31 000 000	3 100 000	NA
		s.d.	24 200	2420			2 980 000	2 980 000	298 000	NA
		CV%	7	7			10	10	10	NA
	22	N	6	6	2 (2–2)	168 (168–168)	6	6	6	6
		Mean	738 000	73 800			77 200 000	77 200 000	7 720 000	2.49
		s.d.	44 300	4430			10 700 000	10 700 000	1 070 000	0.286
		CV%	6	6			14	14	14	11

50	1	N	6	6	2 (2–2)	168 (168–168)	6	6	6	NA
		Mean	1 950 000	39 000			163 000 000	163 000 000	3 250 000	NA
		s.d.	289 000	5770			13 100 000	13 100 000	262 000	NA
		CV%	15	15			8	8	8	NA
	22	N	6	6	2 (2–2)	168 (168–168)	6	6	6	6
		Mean	3 650 000	73 000			387 000 000	387 000 000	7 730 000	2.38
		s.d.	75 200	1500			34 800 000	34 800 000	696 000	0.119
		CV%	2	2			9	9	9	5

200	1	N	10	10	2 (2–2)	168 (168–168)	10	10	10	NA
		Mean	7 330 000	36 600			666 000 000	6 660 000 000	3 330 000	NA
		s.d.	670 000	3350			61 500 000	61 500 000	308 000	NA
		CV%	9	9			9	9	9	NA
	22	N	10	10	2 (2–96)	168 (168–1512)	10	10	10	10
		Mean	17 800 000	89 200			3 180 000 000	1 980 000 000	9 910 000	2.95
		s.d.	4 350 000	21 700			1 160 000 000	652 000 000	3 260 000	0.841
		CV%	24	24			36	33	33	29

Abbreviations: AUC, area under the curve; CV, coefficient of variation; NA, not applicable.

Median (minimum—maximum), median value only reported if actual collection interval.

R=AUC_{0–168 h Day 22}/AUC_{0–168 h Day 1}.

Table 2. Toxicokinetic parameters on days 1 and 22 following intravenous infusion of YYB-101 at 10, 50, or 200 mg kg−1 perday in cynomolgus monkeys (males and females combined).