Table 1.
Effect of injected compounds on resting MAP, HR, SSNA, and RSNA.
| Injected compound | n | MAP, mmHg | HR, beats/min | SSNA, μV | RSNA, μV | ||||
|---|---|---|---|---|---|---|---|---|---|
| Pre | Post | Pre | Post | Pre | Post | Pre | Post | ||
| NS-TG | 6 | 107 ± 6 | 117 ± 6* | 350 ± 7 | 359 ± 6 | 0.03 ± 0.005 | 0.05 ± 0.008* | 0.03 ± 0.009 | 0.05 ± 0.013* |
| 0.75 nmol, PVN | |||||||||
| HS-TG | 6 | 106 ± 4 | 114 ± 5* | 325 ± 14 | 330 ± 15 | 0.04 ± 0.009 | 0.05 ± 0.010* | 0.03 ± 0.006 | 0.03 ± 0.007* |
| 0.75 nmol, PVN | |||||||||
| DMSO, PVN | 3 | 111 ± 7 | 112 ± 6 | 352 ± 35 | 348 ± 34 | 0.03 ± 0.001 | 0.03 ± 0.005 | 0.02 ± 0.003 | 0.02 ± 0.004 |
| Anatomy control (TG outside PVN) | 5 | 111 ± 6 | 112 ± 6 | 337 ± 19 | 334 ± 22 | 0.02 ± 0.002 | 0.02 ± 0.002 | 0.04 ± 0.008 | 0.02 ± 0.007 |
| TG intravenous | 4 | 111 ± 8 | 107 ± 10 | 343 ± 23 | 344 ± 21 | 0.03 ± 0.003 | 0.02 ± 0.003 | 0.04 ± 0.009 | 0.02 ± 0.01 |
Values are mean ± SE; n, number of rats; SSNA, splanchnic sympathetic nerve activity; RSNA, renal sympathetic nerve activity; MAP, mean arterial pressure; HR, heart rate; TG, thapsigargin; PVN, paraventricular nucleus.
*
P < 0.05 vs. pre-treatment.