Table 3. Percentage change in annual notification rate for cases of invasive Haemophilus influenzae disease, by serotype and patient age group, in 12 European countries, 2007–2014*.

Age group	% Change (95% CI), N = 10,574†
	Hib	Hie	Hif	NTHi	Unknown serotype
<1 y	−8.5 (−14.5 to −2.1)	−4.3 (−33.6 to 38.1)	−6.2 (−23.6 to 15.2)	5.5 (0.6 to 10.8)	4.1 (−4.1 to 13.0)
<1 mo‡	–	–	−0.9 (−4.3 to 2.6)	6.2 (2.8 to 9.8)	−0.3 (−19.3 to 23.1)
1–5 mo‡	−25.0 (−32.2 to −17.0)	−2.4 (−72.9 to 251.8)	11.7 (−8.2 to 36.0)	2.1 (−3.3 to 7.7)	−7.1 (−15.6 to 2.4)
6–11 mo‡	3.5 (−18.4 to 31.1)	–	−4.8 (−21.2 to 15.1)	2.7 (−9.7 to 16.8)	24.9 (−2.9 to 60.7)
1–4 y	−18.4 (−32.9 to −0.8)	−14.2 (−25.0 to −1.7)	10.1 (−8.7 to 32.7)	3.8 (−3.4 to 11.6)	2.8 (−9.3 to 16.5)
5–19 y	−8.3 (−26.2 to 14.1)	–	−0.2 (−26.3 to 35.0)	5.3 (−4.7 to 16.3)	−4.9 (−20.3 to 13.5)
20–39 y	−15.0 (−29.4 to 2.3)	3.4 (−14.8 to 25.5)	−1.4 (−17.6 to 18.0)	9.7 (5.6 to 13.9)	−8.6 (−16.2 to −0.3)
40–59 y	−9.0 (−14.7 to −3.0)	−3.3 (−19.8 to 16.7)	7.0 (−3.8 to 19.0)	6.8 (2.4 to 11.3)	−6.8 (−11.0 to −2.3)
>60 y	−12.6 (−17.8 to −7.1)	12.7 (−2.9 to 30.8)	7.0 (0.9 to 13.4)	7.0 (4.5 to 9.5)	−6.0 (−12.1 to 0.5)
Total§	−11.9 (−16.0 to −7.5)	6.3 (−5.3 to 19.5)	6.4 (−1.5 to 14.8)	7.4 (5.3 to 9.6)	−4.8 (−9.0 to −0.5)
*The study was conducted in Belgium, Cyprus, the Czech Republic, Denmark, Finland, Ireland, Italy, the Netherlands, Norway, Slovenia, Spain, and the United Kingdom. Data are for a total of 10,574 cases. Hib, H. influenzae serotype b; Hie, serotype e; Hif, serotype f; NTHi, nontypeable H. influenzae; – no cases reported or no trend could be determined. †Bold font indicates statistically significant trends (p = 0.05). ‡For these age groups, data from only 11 countries are included because Spain did not report data on the age of infant cases by month. §Totals do not include data separately shown for infants <1 mo, 1–5 mo, and 6–11 mo of age because those data are included in the <1 y age group.